Omacetaxine

[anjou]

http://www.medicalnewstoday.com/articles/152238.php

First Viable Treatment Option For Highly Resistant Form Of CML May Be Provided By ChemGenex's Omacetaxine

First Viable Treatment Option For Highly Resistant Form Of CML May Be Provided By ChemGenex's Omacetaxine
Main Category: Lymphoma / Leukemia
Also Included In: MRSA / Drug Resistance; Clinical Trials /
ChemGenex Pharmaceuticals Limited (ChemGenex) (ASX:CXS) announced that the latest data from its pivotal study of omacetaxine in patients with T315I-positive chronic myeloid leukemia (CML) was the subject of an oral presentation and discussion at the 2009 American Society of Clinical Oncology (ASCO) Annual Meeting in Orlando, Florida. The open label Phase 2/3 study (CGX-635-CML-202) investigated the use of omacetaxine, administered subcutaneously in CML patients who had failed imatinib and who have the highly drug resistant T315I kinase domain mutation.

[Trott]

Omacetaxine mepesuccinate is an apoptotic agent that induces apoptosis by inhibition of protein synthesis, particularly Mcl-1.It acts independently of tyrosine kinase inhibitors,it has therapeutic advantages for patients who have developed resistance to tyrosine kinase inhibitor therapy.