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03-15-2009, 02:05 PM
Lymphoma, Leukemia, and Myeloma and the primary category of blood-related cancers.


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Lymphoma is a type of cancer that originates in lymphocytes of the immune system. They often originate in lymph nodes, presenting as an enlargement of the node (a tumor). Lymphomas are closely related to lymphoid leukemias, which also originate in lymphocytes but do not form tumors.

Hodgkin Lymphoma (HL), comprising about 11 percent of diagnosed lymphomas, is distinguished from other types by the detected presence of “Reed-Sternberg” (RS) cells. It is most common in young adults and the elderly, less common in middle age. There are approximately 4,400 men and 3,820 women diagnosed each year in the United States. When the disease is detected during early stages, it is one of the more curable forms of cancer.

Non-Hodgkin Lymphomas (NHLs) are a diverse group of hematologic cancers which encompass any lymphoma other than Hodgkin lymphoma. There are approximately 35,450 men and 30,670 women diagnosed with NHL each year in the United States.

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Leukemia is a cancer of the blood or bone marrow and is characterized by an abnormal proliferation of blood cells, usually white blood cells (leukocytes).

Acute leukemia is characterized by the rapid increase of immature blood cells. This crowding makes the bone marrow unable to produce healthy blood cells.

Chronic leukemia is distinguished by the slow build up of relatively mature, but still abnormal, white blood cells over months or years. Whereas acute leukemia must be treated immediately, chronic forms are sometimes monitored for some time before treatment to ensure maximum effectiveness of therapy.

Additionally, the diseases are subdivided according to which kind of blood cell is affected.

In lymphoblastic or lymphocytic leukemias, the cancerous change takes place in a type of marrow cell that normally goes on to form lymphocytes, which are infection-fighting immune system cells. Defective cells which are unable to fight infection crowd out normal cells.

In myeloid or myelogenous leukemias, the cancerous change takes place in a type of marrow cell that normally goes on to form red blood cells, some other types of white cells, and platelets.

Acute Lymphoblastic Leukemia (ALL) and
Acute lymphoblastic leukemia (ALL), also known as acute lymphoblastic leukemia and acute lymphoid leukemia, can be found in people of all ages. It is the most common type of leukemia in children under age 15, though this age group responds particularly well to treatment. It also affects adults and becomes more common at age 45, 65, and beyond. 5,430 people in the United States are expected to be diagnosed with ALL in 2008. A related but less potentially serious condition Myelodysplastic Syndroms (MDS). About 11,000 cases of MDS are detected each year, typically in people ages 70 and over.

Chronic Lymphocytic Leukemia (CLL) most often affects adults over the age of 55. It sometimes occurs in younger adults, but it almost never affects children. Two-thirds of affected people are men. About 15,110 new cases of CLL will be diagnosed in 2008. About 90,179 people are living with CLL, more than any other type of leukemia leukemia.

Acute Myelogenous Leukemia (AML) occurs more commonly in adults than in children, and more commonly in men than women. About 13,300 Americans are diagnosed with AML each year.

Chronic Myelogenous Leukemia (CML) occurs mainly in adults. A very small number of children also develop this disease. About 4,900 cases are detected in the United States each year, and about 21,749 people are living with CML. In CML, a part of chromosome 9 and chromosome 22 trade places, and a cancer gene is made that promotes the production of an unwanted protein.

Chronic Myelogenous Leukemia (CML) occurs mainly in adults. A very small number of children also develop this disease. About 4,900 cases are detected in the United States each year, and about 21,749 people are living with CML. In CML, a part of chromosome 9 and chromosome 22 trade places, and a cancer gene is made that promotes the production of an unwanted protein.

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Myeloma is a cancer of the plasma cells, a type of white blood cell, part of the body's immune system. Normal plasma cells make antibodies, which help fight infection. Myeloma cells cannot help the body fight infection. As the myeloma cells grow in the marrow they crowd out the normal plasma cells, normal white cells, red cells and platelets.

Approximately 15,0000 to 20,000 new cases of myeloma are diagnosed each year, and approximately 45,000 to 63,000 Americans are living with myeloma. Multiple myeloma is the second most prevalent blood cancer (10%) after non-Hodgkin's lymphoma. It represents approximately 1% of all cancers.